Acetyl-L-Carnitine

Taken for Energy, Vitality and Anti-aging

Suggested usage: Take 2 - 3 capsules daily.

Acetyl-l-carnitine is a stabilized form of the amino acid metabolite L-Carnitine and is utilized in the same manner in the body. Acetyl-l-carnitine plays and important role in the transfer and utilization of long-chain fatty acids, which are used in the production of energy.

Biosint^TM pharmaceutical grade Acetyl-L-Carnitine is manufactured in Italy by Sigma Tau Health Sciences which is the premier international clinical research organization for ALC and its uses.

NOTE: Beware of internet brands that claim "pharmaceutical grade acetyl-l-carnitine" but don't include name of manufacturer. There are only two manufacturers in the world who make pharmaceutical grade acetyl-l-carnitine. They are Sigma Tau Health Sciences (Biosint^TM) and Lonza (L-Carnipure^TM). Non-brand ALC is made in China and much less expensive.

Acetyl-l-carnitine is a molecule that occurs naturally in the brain, liver, and kidney. Natural levels of Acetyl-l-carnitine diminish as we age.

Common uses for supplemental Acetyl-l-carnitine:

• To enhance cognition.
• Involved in the metabolism of food into energy.
• Mild mental impairment in the elderly showed a significant improvement of several performances during and after Acetyl-l-carnitine treatment.
• Reports indicate that Acetyl-l-carnitine may be effective in the treatment of dementia.
• Treated Down syndrome patients showed statistically significant improvements of visual memory and attention both in absolute terms and in comparison with the other groups.
• To significantly reduce severity of depressive symptoms in the elderly.
• To significantly improve items measuring quality of life.
• Improve both spatial and temporal memory, and reduce the amount of oxidative damage to RNA in the brain's hippocampus, an area important in memory.Acetyl-l-carnitine is widely used as an energy supplement.
• Studies demonstrate that ALC treatment is efficacious in alleviating symptoms, particularly pain, and improving nerve fiber regeneration and vibration perception in patients with established diabetic neuropathy
• Increase sperm mobility in men.

Alzheimer's

The acetyl group that is part of acetyl-L-carnitine contributes to the production of the neurotransmitter acetylcholine, which is required for mental function. Several double-blind clinical trials suggest that acetyl-L-carnitine delays the progression of Alzheimer’s disease and enhances overall performance in some people with Alzheimer’s disease. Alzheimer’s research has been done with the acetyl-L-carnitine form, rather than the L-carnitine form, of this nutrient.

Several clinical trials have found that acetyl-L-carnitine supplementation delays the progression of Alzheimer’s disease, improves memory, and enhances overall performance in some people with Alzheimer’s disease. Overall, most short-term studies have shown clinical benefits, and most long-term studies (one year) have shown a reduction in the rate of deterioration.

Brain

One double-blind trial has found that acetyl-L-carnitine may be helpful for people with degenerative cerebellar ataxia, a loss of muscular coordination caused by disease in the cerebellum (the hind part of the brain that controls muscle tone and balance).

Several clinical trials suggest that acetyl-L-carnitine delays onset of ARCD and improves overall cognitive function in the elderly. In a controlled clinical trial, acetyl-L-carnitine was given to elderly people with mild cognitive impairment. After 45 days of acetyl-L-carnitine supplementation at 1,500 mg per day, significant improvements in cognitive function (especially memory) were observed. Another large trial of acetyl-L-carnitine for mild cognitive impairment in the elderly found that 1,500 mg per day for 90 days significantly improved memory, mood, and responses to stress. The favorable effects persisted at least 30 days after treatment was discontinued. Controlled and uncontrolled clinical trials on acetyl-L-carnitine corroborate these findings.

Depression

Acetyl-L-carnitine may be effective for depression experienced by the elderly. A preliminary trial found that acetyl-L-carnitine supplementation was effective at relieving depression in a group of elderly people, particularly those showing more serious clinical symptoms. These results were confirmed in another similar clinical trial. In that trial, participants received either 500 mg three times a day of acetyl-L-carnitine or a matching placebo. Those receiving acetyl-L-carnitine experienced significantly reduced symptoms of depression compared to those receiving placebo. At least two other clinical studies of acetyl-L-carnitine for depression in the elderly have reported similar results.

Drug interactions:

Are there any drug interactions? A. Didanosine (Depletion or interference) Didanosine is a drug that blocks reproduction of the human immunodeficiency virus (HIV). HIV is the virus that infects people causing acquired immunodeficiency syndrome (AIDS). Didanosine is used in combination with other drugs to treat HIV infection.

Acetyl-l-carnitine suggested dosage is 500 mg two to three times daily.

Other product related news:

Carnitine Supplement Helps Sperm Swim

By David Douglas

NEW YORK (Reuters Health) - Taking carnitine supplements seems to improve sperm mobility in men with poorly active sperm, a problem known as asthenozoospermia, Italian researchers report.

However, for carnitine to work, tiny structures within the cell called mitochondria must function properly. Mitochondria are important because they provide the energy needed for sperm to move their tail and "swim."

Senior investigator Dr. Carlo Foresta told Reuters Health that "it is well known that in some asthenozoospermic subjects an improvement of sperm (motion occurs) after carnitine administration...However in other asthenozoospermic patients this effect is not present."

To investigate further, Foresta of the University of Padua and colleagues studied 30 asthenozoospermic men divided into two groups depending on whether they had normal or abnormal mitochondria function. The researchers' findings appear in the medical journal Fertility & Sterility.

In patients with normal mitochondria function, movement rose from 29.3 percent before treatment to 41.1 percent after 3 months of carnitine. However, in those with abnormal function, movement held steady at about 24 percent.

Thus, Foresta concluded that carnitine treatment is useful "in ameliorating sperm motility only when optimal...mitochondrial function ... is conserved."

SOURCE: Fertility & Sterility 2005.

R-Alpha Lipoic Acid
Pure pharmaceutical grade R-form ALA
100 mg x 120 vegetarian capsules
Biotin added for enhanced absorption

Super Energy, Vitality, Anti-aging
Antioxidant Formula

You will notice the difference in energy levels and general well-being.

Each 1 capsule contains:
R-Alpha Lipoic Acid 100 mg
Biotin 100 mcg

Suggested usage: Take 2 - 3 capsules daily.

Biosynergy's pure natural R-Alpha Lipoic Acid (R-ALA), and active isomer of Lipoic Acid, is easily synthesized and metabolized by the body. R-ALA is 2 times more effective than regular (RS) Alpha Lipoic Acid and is a key component of mitochondrial dehydrogenase, which may help to slow the natural aging process in animals. Alpha lipoic acid is known as the "universal antioxidant" because of its unique solubility in both water and fat. It has the ability to conserve and prolong the life of vitamins C & E in the body, increasing their effectiveness. Alpha lipoic acid is also an excellent metal detoxifier, particularly for mercury and cadmium, which it binds to and neutralizes for excretion.

Alpha Lipoic Acid serves as a coenzyme in the energy production process in the cells which can provide quick bursts of energy. Alpha Lipoic Acid is unique in that it is both water and fat soluble which allows it to enter all parts of the cell to neutralize free radicals. Alpha Lipoic Acid contributes to invigorating mental and physical energy and a reduction in muscle fatigue. Dr. Lester Packer, a leading researcher in the area of antioxidants and a professor of molecular and cell biology at the University of California at Berkeley says "Alpha-Lipoic acid could have far-reaching consequences in the search for prevention and therapy of chronic degenerative diseases such as diabetes and cardiovascular disease" .... "and because it’s the only antioxidant that can easily get into the brain, it could be useful in preventing damage from a stroke".

Common uses for supplemental alpha Lipoic Acid:

• Currently used in Europe to treat peripheral nerve degeneration (neuropathy) resulting from diabetes.
• May play a role in controlling blood sugar.
• May help prevent the onset of type 2 diabetes.
• Important for the production of energy inside the cell by utilizing sugar to produce energy contributing to mental and physical stamina.
• Neutralizes free radicals. Unlike Vitamin C which is water soluble and Vitamin E which is fat soluble, alpha Lipoic Acid is both water and fat soluble which allows it to enter all parts of the cell to neutralize free radicals.
• May help reduce LDL (bad) blood cholesterol.
• May help improve memory.
• Chelates (grabs) heavy metals and binds them reducing these oxidants from blood system.
• Inhibits Glycation which is responsible for accelerated tissue damage.
• Recycles and enhances the effects of other antioxidants such as Vitamin E and Vitamin C.
• Significantly increase survival in rats that have suffered a stroke if given before the stroke occurs.
• Prevents tissue damage and death after a heart attack.
• Not only does it act as an antioxidant itself, it also stimulates production of glutathione (an antioxidant produced by the body), giving cells a double dose of antioxidant.
• Easily absorbed when taken orally and once inside cells is quickly converted to its most potent form, dihydrolipoic acid.
• Because both alpha lipoic acid and dihydrolipoic acid are antioxidants, their combined actions give them greater antioxidant potency than any natural antioxidant now known.
• Important for regulating aspects of the immune system, in particular immune cells called T-lymphocytes.
• May be useful in relieving syptoms of stomatopyrosis, or Burning Mouth Syndrome (BMS).

Suggested dosage for R-Alpha Lipoic Acid is 100 mg two to three times daily.

Other product related news:

October 11, 2002. The incidence of inflammatory diseases such as arthritis increases with age. Free radicals promote inflammatory reactions, which antioxidants have been successful at diminishing. Scientists recently stimulated the inflammatory response of white blood cells, resulting in an increase of Intracellular Adhesion Molecule 1 (ICAM-1), which encourages white blood cells to stick to other cells, thereby inflaming tissues. Alpha-lipoic acid, a potent antioxidant, was then added to the mix. Researchers said the acid reduced the activity of ICAM-1 to levels in normal, un-stimulated cells in a dose-dependent manner. It also lowered the activity of NFkB (NFkB can increase the activity of genes responsible for inflammation). According to the study, these changes suggest that alpha-lipoic acid may help reduce the effects of inflammatory diseases such a rheumatoid arthritis and psoriasis.

The above statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

- Acetyl-l-carnitine and Alpha Lipoic Acid in one capsule -
BioEndurance: Acetyl-l-carnitine, alpha lipoic acid, and CoQ10

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