Glucosamine & Chondroitin are naturally occurring structural components that have enjoyed growing popularity recently. Glucosamine is an amino sugar derived from the chitin of shell fish and is used by the body to support healthy joint structures. Chondroitin complements Glucosamine and works synergistically with it to provide optimal nutritional support.

Suggested Usage: As a dietary supplement, take tablets times daily with meals or on an empty stomach.

Glucosamine sulfate, a constituent of cartilage, is a small molecule that is easily absorbed into the blood and joints when taken as a supplement. Glucosamine sulfate has been shown to decrease pain and improve joint function in osteoarthritis patients.

Glucosamine sulfate-as well as the related compound chondroitin sulfate and formulas that combine the two are sold as effective remedies for osteoarthritis. Evidence from studies in Asia and Europe shows that daily supplementation reduces pain and eases mobility in osteoarthritis patients.

Some findings:

A double-blind clinical study on 178 Chinese osteoarthritis patients carried out in Beijing, China, reported the effectiveness of glucosamine sulfate in reducing pain. The patients had osteoarthritis of the knee and were randomized into two groups. One group received 1,500 mg/day Glucosamine sulfate in three divided doses-the standard therapeutic dose. The other group received 1,200 mg/day ibuprofen, a popular non-steroidal anti-inflammatory drug. Researchers then evaluated knee swelling and pain at rest, at movement and with pressure. After two weeks, patients showed symptom improvement with both glucosamine and ibuprofen butt glucosamine generally showed a stronger effect and was better tolerated than ibuprofen. (Qui GX, et al. Efficiency and safety of glucosamine sulfate versus ibuprofen in patients with knee osteoarthritis, Arzneimittelforschung 1998;48:469-74)

In another double-blind study, 252 German patients with osteoarthritis of the knee received 1,500 mg/day glucosamine sulfate in three divided doses. After four weeks, glucosamine sulfate was more effective than placebo in reducing pain and improving mobility. (Noak W, et al. Glucosamine sulfate in osteoarthritis of the knee, Osteoarthritis 1994;2:51-19)

A synthesis of data from several studies on glucosamine sulfate given orally, intravenously or injected into the muscle or joints of osteoarthritis patients shows that glucosamine gradually lowers joint pain and tenderness while improving ease of movement and walking speed. One meta-analysis of studies conducted mostly in Europe and Asia performed by researchers at the School of Pharmacy at Campbell University in North Carolina reports glucosamine sulfate produces an overall 50 percent improvement in pain and mobility in patients. (de Camara CC, Dowless GV. Glucosamine sulfate for osteoarthritis. Ann Pharmacother 1998;21:580-7)

A recent review of two meta-analyses, conducted at Case Western Reserve University School of Medicine in Cleveland, Ohio, reported positive effects of glucosamine sulfate for treating knee and hip osteoarthritis. (Delafuente JC. Glucosamine in the treatment of osteoarthritis. Rheum Dis Clin Northe Am 2000;26:1-11)

A recent review of two meta-analyses, conducted at Case Western Reserve University School of Medicine in Cleveland, Ohio, reported positive effect of glucosamine sulfate for treating knee and hip osteoarthritis. The amount generally administered was 1,5000 mg/day glucosamine sulfate. The review included six double-blind, placebo-controlled trials that lasted longer than four weeks. The authors saw the trial, as positive if pain and joint motion improved in the treatment group by 25 percent more the placebo. Glucosamine proved to be from 17.6 to 61.4 percent better than controls. The authors concluded that glucosamine showed a "substantial benefit" for treating osteoarthritis. (Deal CL, Moskowitz RW. Nutraceuticals as therapeutic agents in osteoarthritis. The role of glucosamine, chondroitin sulfate, and collagen hydrolysate. Rheum Dis Clin North Am 1999;24:379-95)

The above statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

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